I have the very same problem with my Yamaha AG06 mixer. And it’s definitely not a device problem, as it works smoothly on Linux Laptop (even via USB3 hub on my Dell display with USB3 KVM integrated). But when I used it on my W10 desktop I had all of the described problems. Sound is glitching and more of that, rewinding the video on Youtube stops the sound until I restart the device.
I tried all of the proposed solutions - disabling network, direct USB2 connection, different cables, old drivers, disabling the Power Management and economy mode (strange that nothing of that affects Linux machine). Older drivers were ‘the best’ solution - now my sound only glitches once per 10 seconds without stopping the video. But that’s definitely a huge problem with drivers. Shame on Steinberg it’s not resolved yet.