Hi,
I encountered a similar problem. In case, the “culprit” is Proximity EQ by Sonible. If bypassed : no hitch. Same, if I have a lead in gap of 150ms at the start. As if W10 (and 9.5) needs some extra time for getting the plugin chain up to speed.
Did you ever take this to Steinberg support ? I found another similar report in the english forum, that makes 3 already with 3 different plugins !