Thanks for the suggestion, I already tried it with my soundcard as primary audio device and the UR44C only as the recording device. However, still neither Cubase nor Guitarrig could detect it.
I am wondering why the DSPMX-software works. What does it do that makes it different from Cubase and Guitarrig. Is it just meant to control the UR44C internal DSP?
Misohoza, if you chose it as your playback device, can you playback e.g. the sound from a Youtube-video on the speakers connected to the UR44C or can anyone test that? Every audio interface should be able to do what a soundcard does because it is (among other things) basically a soundcard.
I also researched on problems regarding the UR44 (without “C”) and one user had a comparable issue with Windows 10 because he had the “CC Mode” switch on which had to be done on a UR44 to operate it with iOS. I looked into the manual and on the device and I cannot find such a switch. Is it gone on the UR44C?