I also started having Midi Timing Issues when I updated from Cubase Pro 9.5 to Cubase 10 and still with Cubase 10.5. Windows 10, latest updates, MOTU MTP AV USB Interface with their latest driver. Midi simply chokes and notes do not sound and then they resumes. No matter if it is a Midi track with notes on it or simply playing with Monitoring On and Cubase stopped. Never had this happen in Cubase before. Very, very annoying.