I am also having a similar issue.
Running the current (1.10.4 I believe) drivers on Windows 10 x64
I’ll be in the middle of recording, or even just watching netflix or something and the audio will become garbled and distorted. I need to hard reset the UR 22 with the power button to fix it. Sometimes it will go 2 minutes before exploding again and sometimes it will go an hour. Totally random. Have tried changing to a different USB port and that did not fix the issue.
I never had issues like this until recently (perhaps 1-2 months ago?) so perhaps its a windows update issue?
Please help!