UR 22 mk2 crackle and distortion problem

That is great news! Thanks for sharing!
Yes, there is more info on the settings:

Flag Override (default Auto):
Customer choose one from three selections, Low Latency, Standard, and Stable.
Low Latency = The option shorten the general communication speed between a driver and a PC however it might trade-offs stability.
Standard = It’s a well balanced setting between shorter latency and stability.
Stable = Longer latency brings more stability.

Base Period (default Auto):
Under both WDM and ASIO circumstances, the option can change the operation cycle. Input latency gets lower with a lower setting but it causes high CPU load.

ISO Extra Buffer (default Auto)
It determines the output buffer size on ASIO. Choosing a lower amount results in lower output latency but it might produce noise at high CPU loads.

USB Frame Continuous Sync (default off)
We witnessed 500ms~800ms time stamp jumps in the USB streaming from PCs during our tests, and we concluded that some (or many?) PCs don’t generate a proper USB time stamp that our previous drivers refer to, for the synchronization between input and output. From the version 1.10.1 for Windows, our driver check the time stamp information only at beginning, and it will free-run after that. In result, the problem should disappear.

Skip Initial Samples (default off):
Audio driver might send a chunk of non-audio signal just before starting to transmit audio data. The signal disturbs synchronization between Input and Output.
The option prevents such a case by ignoring the unnecessary signal.

Overload Detection (default on):
Audio driver informs DAW about a condition when CPU load gets close to overflow, then a DAW notices the user with a peak lump. Previous driver showed excessive reactions in several cases.