Still same Problem, after the new UR824 Update. I will write to the support. We all should, if Problem still remains by your setuo too. My Hardware Setup is gone everys time. No matter if Cubase crashes before or not. It must have something to do with a special file in die App Data Folder of Cubase on Windows. If you replace it with an version, which was saved before quitting Cubase the first time after instalation , the hardware setup is Back again. I already make jokes on my self to replayce the Cubase App Data "Preset folde rby each Windows Satartup with an Sync-Application. 
. I just don’t have figured out which file in the Preset-Folder is in connection with this.