Yes I know, RME is extremely reliable, I’m using RME cards since about 10 years too. The only issue I got was about the Vista>W7 soft upgrade. It was not compatible with RME drivers and I had to proceed the full hard upgrade and reinstall all apps. That’s the only one… Well, not exactly, I got 2xTCO, one was out of service, the other one doesn’t work too… Apart from that, not a single problem with any RME main board, Hamerfall DSP, Madi, RayDAT etc…
I’ll keep on searching, something wrong in ASIO between Nuendo and TM maybe… Really don’t understand what’s happening 