I got the exact same issue, and the same error messages using the UR-RT4 on my desktop computer, I’ve tried everything metioned above too and no real results, it seems to be worse when i try yo play a vidéo on VLC or on Youtube as well. but it sometimes happen when i’m using Pro tools too.
There’s this message in the control panel:
“Audio interruption due to USB error is detected. Refer to the troubleshooting in the operation manual.”
also the event “Device was not migrated due to partial or ambiguous match” is showing in the device properties (Device Manager > Steinberg UR-RT4 > Properties > Events).
My specs are:
Motherboard: Gigabyte X99-Ultra Gaming-CF
Processor: Intel(R) Core™ i7-6800K CPU @ 3.40Ghz 340Ghz
Memory: 32Go RAM
Graphic card: NVIDIA GeForce GTX 1080
Windows 10 Enterprise LTSC
Yamaha Steinberg USB Driver V2.0.3 for Windows
Hope you can help us.