Hi I have had this exact same issue tonight on my 10.5.20 installation. It may be irrelevant but I had left my pc in sleep mode rather than shut down something I do not usually do. SubsequentLy Cubase crashed when I restarted the pc and I had difficulty restarting. Then I found I have this issue. Restarted but no change. I’m using a Yamaha UR22 Mk 1 interface.
Regards
Geoff