Hey Dietz,
I suspected that something had changed with Nuendo 10.3 and graphics, so I basically just kept changing settings on my graphic card until it worked again. 
I’m running an NVidia GForce GTX 1060. I wish there was a way to export all of the settings for you. If you still have problems I’ll write all of the settings down.
I recently updated the NVidia driver and was back to the same problem - kept changing stuff until it worked again. I’ve noticed that 10.3 runs better with the graphics changes which immediately says to me that there are some issues with Nuendo/W10/graphics
I informed the Vertigo support guys that the VSC3 was the only plugin in my collection that was exhibiting this problem.
The Nuendo development team will probably fix the graphics bugs soon enough, because these bugs are actually affecting performance.