I’m having the same problem with Analog Lab 4 on an iMac (27", 5K retina, 2017) using Cubase Pro 10.5. No problems using it with Reaper, as a standalone, or with prior releases of Cubase–9.5, 10, etc…
Aside: Guess that’s why Steinberg put in the “safe mode” startup “feature” in 10.5, allowing you to disable 3rd party plugins. Just when I was considering buying a new 3rd party plugin! Hope this is fixed SOON.