I am having the same issue. my latencyMon shows very low execution time and i get lots of random pops and crackles. I just spent hours troubleshooting. I even put my buffer size up to 512 and same thing. I do software support and already ran tools like ‘windows performance recorder’ to try and trace if there were any issues with my OS or interrupts with the CPU but there is none.
Steinberg I do software support for a living so if you need any traces on this let me know!! Seems like a lot of people are having the issue upgrading from 9.5 > 10 and experiencing pops.