total noob question, mic and guitar

thinking about it the answer probably is a dynamic and a usb, so i can skype ideas through to others through usb on my laptop whilst using my desktop with the c1, but for reference sake, the question is still there. I understand the XLR will be hitting different pins in the inplug compared to the unbalanced guitar cable, so is it safe to assume that with phantom power on, line 1 will still behave as a hi-z input, and not be sending 48 volts back into my guitar pots?