Depends on exactly what you mean by ‘spatial audio’ (Binaural, Ambisonics, Gaming VR formats etc). For binaural work, these are very nice indeed and have been using with Nuendo 10: DearVR Music, DearVR Pro, New Audio Technology Spatial Audio Designer. Both companies have gaming engines. I find that DearVR have truly excellent sound, verbs, and early reflections in particular; SAD also is nice, but the bussing, mixing and multiple speaker options are far more advanced.