Yes I have noticed that and I have not been able to pin down the cause or a Repro. For a while during the Nuendo 7 and 8 era it happened fairly frequently.
I will have to say that I have not seen it thus far in Nuendo 10. I hadn’t really thought about that until I saw your post and realized I have not dealt with the issue in a good while.
One thing I noticed is both of us are using RME Hardware. I would like to know if this problem presents with people using other Hardware.