Cubase 10 Re-Install - Is It Safe To Do So?

You should be fine reinstalling CB. If you are using all your versions of CB and are experiencing the same problem then replace all of them. Otherwise, just reinstall the version you use most. I would save the prefs just in case that wasn’t your problem but use the fresh prefs initially.
All the info to make your songs load correctly are in the CPR song files so you should have no problems as long as all your paths to your audio files are the same. I always make sure my audio files are in the same folder as the CPR file so they’re easy to locate in the event that a folder is moved.
Good luck.