Noise is most often caused by the gain, or amplification, turned up too high at some point, either on the monitor, from within the software, or from the audio interface. Check the levels of your interface, software, and speakers to make sure that nothing is being over-amplified.
Popping, clicking, crackling, or other similar sounds are usually the result of a software/driver issue with the interface. The most common reasons for these sounds to occur include having the interface’s “buffer” set too low, the presence of wireless or BlueTooth adapters running on the system, or a software incompatibility. Check with support for your particular interface for any issues involving incompatibilities, and make sure your computer meets the minimum system requirements for your hardware and software.
If you are experiencing these sounds, you will want to isolate the speakers from the interface and check the interface with a different playback system, such as headphones - this would verify where the noise is coming from.