I don’t think there are many reasons to worry when using multicore processors for real life use. Here’s a link to a test I made with my new 3900X https://www.gearslutz.com/board/showpost.php?p=14333456&postcount=830
As you can see Cubase balances the cores perfectly with AG on.
The caveat, as I understand it, is that when you arm a track that track gets processed as if AG is off. So if you arm many tracks processor balancing gets worse. So to be safe from dropouts, don’t put your heaviest plugins on tracks you want to record to. Or on the master track, for that matter.