Hello to everyone… As i saw in the forum there are some Topics talking for the same issue but topics are not answered yet. So I will try mine 
Well, ur22 mk2 was plugged into a very old laptop with no issues at all. For my “bad luck” i built a great tower now and the last thing i could thing was
that the audio interface will not work…
Issues : when i turn on the ur22 i cannot ever listen to a youtube video.
of course in Cubase i cant do NOTHING 
i tryed to change oparating system also cause i tried so many possible “sollutions” but nothing fix the issue…
I hope that someone will help me and the other users to solve that problem… 